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Obesity therapeutics: Unmet needs Current GLP-1 agonist therapies approved for chronic weight management have proven to be effective by reducing gastric motility and increasing the sense of fullness, causing reduced food intake and rapid weight loss

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The bioavailability of nitric oxide (NO), which is a major vasodilator, is highly dependent on the redox status

Consequently, tissue-level outcomes may depend not only on receptor activation but also on the availability of metabolic substrates required to sustain bioenergetic and redox balance under conditions of reduced nutrient inflow